BX 513 hydrochloride, Tocris Bioscience™

Description

Selective CCR1 antagonist

Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.

Specifications

Chemical Identifiers

• CAS: 1216540-18-9
• Molecular Formula: C28H30Cl2N2O
• Molecular Weight (g/mol): 481.461
• InChI Key: SSZWNUGWOGONQJ-UHFFFAOYSA-N
• Synonym: bx 513 hydrochloride, bx-513 hydrochloride, 1-piperidinepentanenitrile,4-4-chlorophenyl-4-hydroxy-a,a-diphenyl-,hydrochloride, 4-4-chlorophenyl-4-hydroxy-?,?-diphenyl-1-piperidinepentanenitrile hydrochloride, 5-4-4-chlorophenyl-4-hydroxypiperidin-1-yl-2,2-diphenylpentanenitrile hydrochloride, 5-4-4-chlorophenyl-4-hydroxypiperidin-1-yl-2,2-diphenylpentanenitrile-hydrogen chloride 1/1
• PubChem CID: 56972186
• IUPAC Name: 5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile;hydrochloride
• SMILES: C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4.Cl

• Quantity: 10 mg
• Formula Weight: 481.46
• Percent Purity: >99%
• Chemical Name or Material: BX 513 hydrochloride