c-Cbl Monoclonal Antibody (S.551.7), Invitrogen™

Rabbit Monoclonal Antibody

Brand:  Invitrogen MA514955

Product Code. 11574921

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with Cbl-b or Cbl-c proteins.

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Specifications

• Antigen: c-Cbl
• Classification: Monoclonal
• Concentration: 18.6 μg/mL
• Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
• Gene Accession No.: P22681
• Gene Symbols: Cbl
• Immunogen: Synthetic peptide corresponding to the sequence of human c-Cbl
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Non-human Primate
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunoprecipitation, Western Blot
• Clone: S.551.7
• Conjugate: Unconjugated
• Gene: Cbl
• Gene Alias: 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 867
• Content And Storage: -20°C
• Form: Liquid