Calcitriol, Tocris Bioscience™

Description

Vitamin D receptor (VDR) agonist

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Specifications

• CAS: 32222-06-3
• Molecular Formula: C27H44O3
• MDL Number: MFCD00867079,MFCD11656129
• Quantity: 50 μg
• Synonym: calcitriol, rocaltrol, calcijex, topitriol, 1alpha,25-dihydroxyvitamin d3, silkis, soltriol, 1alpha,25-dihydroxycholecalciferol, calcitriolum, dihydroxyvitamin d3
• InChI Key: GMRQFYUYWCNGIN-NKMMMXOESA-N
• SMILES: C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
• IUPAC Name: (1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• Molecular Weight (g/mol): 416.65
• PubChem CID: 5280453
• ChEBI: CHEBI:17823
• Formula Weight: 416.64
• Percent Purity: >99%
• Chemical Name or Material: Calcitriol