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Casc5 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA555360
This item is not returnable.
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Description
Immunogen sequence: HHTEEDIDKS ANSVLIKNLS RTPSSCSSSL DSIKADGTSL DFSTYRSSQM ESQFLRDTIC EESLREKLQD GRITIREFFI LLQVHILIQK PRQSNLPGNF TVNTPPTPED LMLSQYVYRP KIQIYREDCE ARRQKIEELK LSASNQDKL Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 81%.
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.Specifications
Casc5 | |
Polyclonal | |
Unconjugated | |
KNL1 | |
2310043D08Rik; 5730505K17Rik; AF15Q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; kinetochore null 1 homolog; kinetochore scaffold 1; Kinetochore-null protein 1; KNL1; MCPH4; microcephaly, primary autosomal recessive 4; PPP1R55; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; Rad51; RAD51 homolog; Spc7 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
57082 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8NG31 | |
KNL1 | |
Recombinant protein corresponding to Human Casc5 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only