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CD160 Monoclonal Antibody (eBioCNX46-3 (CNX46-3)), PE, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Brand: Invitrogen 12-1601-81
Description
Description: CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRgammadelta T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus. Applications Reported: This eBioCNX46-3 (CNX46-3) antibody has been reported for use in flow cytometric analysis. Applications Tested: This eBioCNX46-3 (CNX46-3) antibody has been tested by flow cytometric analysis of C57Bl/6 mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. It is involved in cell proliferation, cell surface receptor signaling pathways, cellular defense response, and regulation of immune response.Specifications
CD160 | |
Monoclonal | |
0.2 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
O88875 | |
CD160 | |
Affinity chromatography | |
RUO | |
54215 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
eBioCNX46-3 (CNX46-3) | |
PE | |
CD160 | |
AU045688; BY55; CD160; CD160 antigen; CD160 antigen, soluble form; CD160 molecule; CD160 transmembrane isoform; CD160-delta Ig; natural killer cell BY55; natural killer cell receptor; natural killer cell receptor BY55; natural killer cell receptor, immunoglobulin superfamily member; NK1; NK28; RGD1563598 | |
Rat | |
50 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2a κ |
For Research Use Only.