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CD278 (ICOS) Monoclonal Antibody (7E.17G9), Biotin, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Brand: Invitrogen 13-9942-85
Description
Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells. Applications Reported: 7E.17G9 has been reported for use in flow cytometric analysis. Applications Tested: The 7E.17G9 antibody has been tested by flow cytometric analysis of unstimulated and Con A-stimulated (3 day) mouse splenocytes and can be used at less than or equal to 0.06 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.
ICOS (CD278) encodes a protein that is a member of the CD28 and CTLA-4 cell-surface receptor family. It functions as a homodimer and has a crucial role in cell-cell signaling, immune responses, and the regulation of cell proliferation. ICOS has been linked to various disorders, including Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.Specifications
CD278 (ICOS) | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.2 | |
Q9WVS0 | |
ICOS | |
Affinity chromatography | |
RUO | |
54167 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
7E.17G9 | |
Biotin | |
ICOS | |
Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115 | |
Rat | |
500 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2b κ |
For Research Use Only.