Learn More
CD314 (NKG2D) Monoclonal Antibody (1D11), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£205.00 - £220.00
Specifications
Antigen | CD314 (NKG2D) |
---|---|
Clone | 1D11 |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | APC |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15310770
|
Invitrogen
17-5878-81 |
50 μg |
£205.00
50µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
15598146
|
Invitrogen
17-5878-42 |
100 Tests |
£220.00
100 tests |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Description: The 1D11 monoclonal antibody reacts with the human NKG2D, a 42 kDa lectin-like molecule expressed by NK cells, gamma delta T cells, CD8+ T cells, and some CD4+ T cells. Human NKG2D forms complexes with DAP10, a membrane adaptor protein, and has the ability to costimulate multiple NK activation receptors. The counter-receptor for human NKG2D has been identified as MICA/MICB expressed on epithelial tumors from lung, breast, kidney, ovary, prostate and colon carcinoma. 5C6 and 1D11 block binding of soluble MICA to gamma delta TCR T cell clones and inhibit lysis by these cells. 5C6 and 1D11 induced NKG2D function of redirected lysis of FcReceptor bearing P815 cells. Applications Reported: The 1D11 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1D11 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.Specifications
CD314 (NKG2D) | |
Flow Cytometry | |
APC | |
Mouse | |
Human | |
CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D | |
Klrk1 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Klrk1 |
1D11 | |
Monoclonal | |
Liquid | |
RUO | |
P26718 | |
22914 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.