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CD326 (EpCAM) Monoclonal Antibody (G8.8), Brilliant Violet™ 711, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£152.00 - £312.00
Specifications
Antigen | CD326 (EpCAM) |
---|---|
Clone | G8.8 |
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17971991
|
Invitrogen
407-5791-82 |
100 μg |
£312.00
100µg |
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17972031
|
Invitrogen
407-5791-80 |
25 μg |
£152.00
25µg |
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Description
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is highly expressed in human carcinomas, and is a marker for tumors of epithelial lineage. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and many carcinoma types. Also, Ep-CAM reportedly distinguishes adenocarcinomas from pleural mesotheliomas.Specifications
CD326 (EpCAM) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
adenocarcinoma-associated antigen; CD326; cell surface glycoprotein Trop-1; DIAR5; EGP; EGP-2; EGP314; EGP40; EPCAM; Ep-CAM; EpCAM1; epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; gp40; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; Ly74; lymphocyte antigen 74; M1S2; M4S1; major gastrointestinal tumor-associated protein GA733-2; mEGP314; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; panepithelial glycoprotein 314; protein 289A; Protein D5.7A; Tacsd1; Tacstd1; TROP1; Trop-1 protein; Tumor-associated calcium signal transducer 1 | |
EPCAM | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
G8.8 | |
Flow Cytometry | |
Brilliant Violet 711 | |
Rat | |
Mouse | |
Q99JW5 | |
17075 | |
IgG2a κ | |
Affinity chromatography | |
EPCAM |