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CD335 (NKp46) Monoclonal Antibody (9E2), eFluor™ 450, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£72.75 - £226.00
Specifications
Antigen | CD335 (NKp46) |
---|---|
Clone | 9E2 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Description
Description: This 9E2 monoclonal antibody reacts with human CD335, which is also known as NKp46. Expressed on NK cells, CD335 is a member of the natural cytotoxicity receptor family that also includes NKp30 and NKp44. This type I transmembrane glycoprotein is involved in activating and expanding resting NK cells following interaction with dendritic cells to eliminate tumor and virus-infected (e.g., influenza) cells. CD335 also interacts with pancreatic beta cells during the development of type I diabetes. The 9E2 antibody has been reported to induce cytotoxicity. Applications Reported: This 9E2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 9E2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor™ 450 is an alternative to Pacific Blue™. eFluor™ 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser. Filtration: 0.2 μm post-manufacturing filtered.
NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR).Specifications
CD335 (NKp46) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
O76036 | |
NCR1 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
NCR1 |
9E2 | |
Flow Cytometry | |
eFluor 450 | |
Mouse | |
Human | |
9437 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.