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CD80 Monoclonal Antibody (2A2), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA515512
This item is not returnable.
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Description
MA5-15512 targets CD80 in indirect ELISA, IF and IHC applications and shows reactivity with Human samples. The MA5-15512 immunogen is purified recombinant fragment of CD80 expressed in E. Coli. MA5-15512 detects CD80 which has a predicted molecular weight of approximately 55kDa.
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.Specifications
CD80 | |
Monoclonal | |
Conc. Not Determined | |
ascites with 0.03% sodium azide | |
P33681 | |
CD80 | |
Purified recombinant fragment of CD80 expressed in E. Coli. | |
RUO | |
941 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
ELISA, Immunocytochemistry, Immunohistochemistry | |
2A2 | |
Unconjugated | |
CD80 | |
Activation B7-1 antigen; B7; B7 protein; B7.1; B71; B7-1; B7-1 protein; B7-1 protein precursor; BB1; B-lymphocyte activation antigen B7; Cd28l; CD28LG; CD28LG1; CD80; Cd80 a rat homolog of the human CD28/CTLA - 4 ligand (B7-1); CD80 anitgen; CD80 antigen; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Cd80 molecule; CD80 protein precursor; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; Ly53; Ly-53; MIC17; sCD 80; sCD80; secreted B7-1 protein precursor; soluble CD 80; soluble CD80; T-cell costimulatory molecule; T-cell co-stimulatory protein B7-1; T-lymphocyte activation antigen CD80; TS/A-1; TSA1 | |
Mouse | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |