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CDK4 Antibody Cocktail, Invitrogen™
Antibody Cocktail
Brand: Invitrogen MA513720
This item is not returnable.
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Description
MA5-13720 targets Cdk4 in IF, IP, and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-13720 immunogen is purified recombinant cdk4 protein.
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Specifications
| CDK4 | |
| Cocktail | |
| 0.2 mg/mL | |
| PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4 | |
| P11802, P30285, P35426 | |
| Cdk4 | |
| Purified recombinant cdk4 protein | |
| 500 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Immunocytochemistry, Immunoprecipitation, Western Blot | |
| DCS-31, DCS-35 | |
| Unconjugated | |
| Cdk4 | |
| Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34<PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) | |
| Mouse | |
| Protein G | |
| RUO | |
| 1019, 12567, 94201 | |
| 4° C | |
| Liquid |