Invitrogen™ CDK9 Recombinant Human Protein, Inactive

CDK9 is a member of the cyclin-dependent protein kinase family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle. Recombinant full-length human CDK9 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Product Code	Brand	Quantity
15481214	Invitrogen™ PV6304	10 μg
15491214	Invitrogen™ PV6305	100 μg
15411224	Invitrogen™ PV6306	1 mg

Description

CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS.

• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use

Specifications

• For Use With (Application): Enzyme and Protein Activity Assay, Industrial and Applied Science, Kinase Assay, Kinase Biology, Kinase Proteins and Expression Reagents, Pharma and Biopharma, Protein Assays and Analysis, Protein Biology, Target and Lead Identification and Validation
• Molecular Weight (g/mol): 69.1kDa
• Gene Alias: CDC2L4, C-2k, TAK, PITALRE
• Recombinant: Recombinant

• Formulation: 50mM Tris-HCl pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
• Storage Requirements: Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
• Species: Human
• Protein Tag: GST Tag