Cefotaxime sodium salt, Thermo Scientific Chemicals

Description

Cefotaxime sodium salt, CAS # 64485-93-4, is the sodium salt form of cefotaxime with β-lactamase resistant antibiotic activity.

Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• The cefotaxime sodium salt is a - lactamase considered a third-generation cephalosporin with antibiotic and bactericidal activities
• This compound exerts its biological activity by binding to penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall leading to their inactivation. The inactivation of these proteins affects the cross-linking of peptidoglycan chains required for bacterial cell wall strength and rigidity, resulting in the weakening of cell walls and cell lysis.

Applications

• It is an efficient antibacterial compound that acts against gram-negative bacteria, without activity against gram-positive bacteria such as pseudomonas and penicillin-resistant strains of streptococcus pneumonia
• It has been used for plant cell culture and human cell lines in vitro
• Cefotaxime sodium salt has been used in antibiotic susceptibility testing (AST) methods
• Cefotaxime sodium salt is also used to remove bacteria from Ostreococcus tauri cultures

Specifications

Chemical Identifiers

• CAS: 64485-93-4
• Molecular Formula: C16H16N5NaO7S2
• Molecular Weight (g/mol): 477.44
• MDL Number: MFCD00079073
• InChI Key: AZZMGZXNTDTSME-JUZDKLSSSA-M
• PubChem CID: 88631411
• IUPAC Name: sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• SMILES: [Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1

• Type: Cefotaxime Sodium Salt
• Physical Form: Powder
• Color: White to Yellow
• Quantity: 5 g
• Beilstein: 5711411
• Merck Index: 14,1933
• Solubility Information: Soluble in water.
• Formula Weight: 477.4
• Chemical Name or Material: Cefotaxime sodium salt

Safety and Handling

Product Identifier

• Cefotaxime sodium salt

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 2
• Respiratory sensitiser Category 1
• Skin corrosion/irritation Category 2
• Skin sensitiser Category 1
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H317-May cause an allergic skin reaction.
• H319-Causes serious eye irritation.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
• H335-May cause respiratory irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

Supplemental information

• MIXTURE LIST-Contains : Sodium [6R-[6.alpha.,7.beta.(Z)]]-3-(acetoxymethyl) -7-[(2-aminothiazol-4-yl)(methoxyimino)acet amid

RUO – Research Use Only