CGS 9343B, Tocris Bioscience™

Description

Calmodulin antagonist

Calmodulin antagonist; inhibits calmodulin-stimulated cAMP phosphodiesterase activity with an IC50 of 3.3 nM. Also prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.

Specifications

• CAS: 109826-27-9
• Molecular Formula: C30H32N4O6
• MDL Number: MFCD04113002
• Quantity: 10 mg
• Synonym: 1,3-dihydro-1-1-4-methyl-4h,6h-pyrrolo 1,2-a 4,1-benzoxazepin-4-yl methyl-4-piperidinyl-2h-benzimidazol-2-one maleate
• InChI Key: NGODOSILXOFQPH-BTJKTKAUNA-N
• SMILES: OC(=O)\C=C/C(O)=O.CC1(CN2CCC(CC2)N2C(=O)NC3=CC=CC=C23)OCC2=CC=CC=C2N2C=CC=C12
• IUPAC Name: (2Z)-but-2-enedioic acid; 1-[1-({7-methyl-8-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,10,12-pentaen-7-yl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one
• Molecular Weight (g/mol): 544.61
• PubChem CID: 14171586
• Formula Weight: 544.61
• Percent Purity: >98%
• Chemical Name or Material: CGS 9343B