Ch 55, Tocris Bioscience™

Description

Potent RAR agonist

Highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM).

Specifications

Chemical Identifiers

• CAS: 110368-33-7
• Molecular Formula: C24H28O3
• Molecular Weight (g/mol): 364.485
• InChI Key: FOUVTBKPJRMLPE-FMIVXFBMSA-N
• Synonym: 3,5-di-tert-butylchalcone, 4-1e-3-3,5-di-tert-butylphenyl-3-oxoprop-1-en-1-yl benzoic acid, 4-3-3,5-di-t-butylphenyl-3-oxo-1-propenyl benzoic acid, e-4-3-3,5-bis 1,1-dimethylethyl phenyl-3-oxo-1-propenyl benzoic acid, benzoic acid, 4-3-3,5-bis 1,1-dimethylethyl phenyl-3-oxo-1-propenyl-, e, 3,5-di-tert-butylchalcone-4'-carboxylic acid, e-4-3,5-di-t-butylphenyl-3-oxopropenyl benzoic acid, 4-3-3,5-di-tert-butylphenyl-3-oxo-1-propenyl benzoic acid, 4-e-3-3,5-ditert-butylphenyl-3-oxo-prop-1-enyl benzoic acid, 4-e-3-3,5-ditert-butylphenyl-3-oxoprop-1-enyl benzoic acid
• PubChem CID: 6184667
• IUPAC Name: 4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid
• SMILES: CC(C)(C)C1=CC(=CC(=C1)C(=O)C=CC2=CC=C(C=C2)C(=O)O)C(C)(C)C

• Quantity: 50 mg
• Formula Weight: 364.47
• Percent Purity: >98%
• Chemical Name or Material: Ch 55