Chloromethyl chloroformate, 97%, Thermo Scientific Chemicals

Description

Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.

Solubility
Slightly miscible with water.

Notes
Incompatible with oxidizing agents and water.

Specifications

Chemical Identifiers

• CAS: 22128-62-7
• Molecular Formula: C2H2Cl2O2
• Molecular Weight (g/mol): 128.936
• MDL Number: MFCD00077688
• InChI Key: JYWJULGYGOLCGW-UHFFFAOYSA-N
• Synonym: chloromethyl chloroformate, chloromethylchloroformate, chloroformic acid chloromethyl ester, carbonochloridic acid, chloromethyl ester, palite, chlormethylchlorformiat, clco2ch2cl, chlormethylchlorocarbonat, chloromethyl choroformate, choromethyl chloroformate
• PubChem CID: 62754
• IUPAC Name: chloromethyl carbonochloridate
• SMILES: C(OC(=O)Cl)Cl

• Melting Point: <-20°C
• Density: 1.465
• Boiling Point: 107°C to 108°C
• Flash Point: 95°C (203°F)
• Odor: Acrid
• Linear Formula: ClCO₂CH₂Cl
• Refractive Index: 1.4295
• Quantity: 50 g
• UN Number: UN2745
• Beilstein: 506426
• Sensitivity: Moisture sensitive
• Solubility Information: Slightly miscible with water.
• Formula Weight: 128.94
• Percent Purity: 97%
• Chemical Name or Material: Chloromethyl chloroformate

Safety and Handling

Product Identifier

• Chloromethyl chloroformate

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 2
• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H302-Harmful if swallowed.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H330-Fatal if inhaled.
• EUH029-Contact with water liberates toxic gas.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Chloromethylchloroformate

RUO – Research Use Only