Chloroquine diphosphate salt, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
15456399	Thermo Scientific Alfa Aesar J64459.14	25 g
15466399	Thermo Scientific Alfa Aesar J64459.22	100 g

Description

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Chloroquine diphosphate salt is a DNA intercalator that shows anti-malarial and anti-inflammatory activities.

• It has been described that this compound interferes with the biosynthesis of nucleic acids, suggesting a cellular mechanism of action

Applications

• Chloroquine diphosphate salt is used as a DNA intercalator to dissociate antigen-antibody complexes without denaturing red blood cell antigens

• This compound shows antimalarial activity against Plasmodium falciparum, except against chloroquine-resistant strains. It has been used in in vitro antiplasmodial assays. In parasites, the mechanism of action remains unclear, but this compound can inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemozoin, resulting in the accumulation of toxic heme within the parasite.

• It shows very high anti-viral activity against NiV but lower activity against other viruses at concentrations lower than 20 μM

• Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs

• Chloroquine diphosphate salt has been used in autophagy inhibition studies

Chemical Identifiers

• CAS: 50-63-5
• Molecular Weight (g/mol): 515.86
• InChI Key: QKICWELGRMTQCR-UHFFFAOYNA-N
• PubChem CID: 64927

• Molecular Formula: C18H32ClN3O8P2
• MDL Number: MFCD00069852
• Synonym: chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
• SMILES: OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1

Specifications

• CAS: 50-63-5
• Color: White
• MDL Number: MFCD00069852
• Merck Index: 14,2163
• Solubility Information: Soluble in water
• SMILES: OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1
• Molecular Weight (g/mol): 515.86
• Formula Weight: 515.87
• Physical Form: Powder

• Melting Point: 213°C to 216°C
• Molecular Formula: C18H32ClN3O8P2
• Beilstein: 4223142
• Synonym: chloroquine diphosphate, chloroquine phosphate, aralen phosphate, chingamin phosphate, chloroquine bis phosphate, chingaminum, alermine, h-stadur, aralen diphosphate, miniquine
• InChI Key: QKICWELGRMTQCR-UHFFFAOYNA-N
• IUPAC Name: 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid
• PubChem CID: 64927
• Percent Purity: 98%
• Chemical Name or Material: Chloroquine diphosphate salt

Safety and Handling

GHS H Statement
H302
Harmful if swallowed.

P264b-P270-P301+P312-P330-P501c

H302

missing translation for 'einecsNumber' : 200-055-2

missing translation for 'rtecsNumber' : VB2450000

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures

RUO – Research Use Only