Chlortetracycline hydrochloride, specified according to the requirements of Ph.Eur., Thermo Scientific Chemicals

Product Code	Brand	Quantity	Packaging
10882041	Thermo Scientific Acros 430960050	5 g	Glass bottle
10785652	Thermo Scientific Acros 430960250	25 g	Glass bottle
10220130	Thermo Scientific Acros 430961000	100 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General features
• Chlortetracycline hydrochloride is a broad-spectrum antibiotic of the tetracycline family
• Receives its name from a 7-chloro substitution on one of the rings of its parent structure, tetracycline
• A bacteriostatic that inhibits the 30S ribosomal subunit and prevents peptide formation
• Can work as an antiprotozoal and antifungal

Applications
• Chlortetracycline is suitable for use in biochemistry, microbiology, in vivo research, and cell culture
• Intended for research use only

Chemical Identifiers

• CAS: 64-72-2
• Molecular Weight (g/mol): 515.33
• InChI Key: QYAPHLRPFNSDNH-CIVPRPTRSA-N
• PubChem CID: 66577600
• SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl

• Molecular Formula: C₂₂H₂₃ClN₂O₈·HCl
• MDL Number: MFCD00082440
• Synonym: chlortetracycline hydrochloride, 4-epi-chlortetracycline hydrochloride, 2-amino hydroxy methylidene-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride, 2-azanyl oxidanyl methylidene-7-chloranyl-4-dimethylamino-6-methyl-6,10,11,12a-tetrakis oxidanyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride
• IUPAC Name: (4S,4aR,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride

Specifications

• CAS: 64-72-2
• Melting Point: 220.0°C
• pH: 2.3 to 3.3 (1% H₂O, CO₂ free)
• Molecular Formula: C₂₂H₂₃ClN₂O₈·HCl
• Merck Index: 15,2198
• Specific Rotation: − 242.50
• Solubility Information: Solubility in water: 8.6g/L (28°C). Other solubilities: practically insoluble in acetone,ether,,chloroform,dioxane and propylene glycol,17.4g/L methanol (28°C),1.7g/L ethanol (28°C),soluble in solutions of alkali hydroxides and,carbonat
• SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O.Cl
• Molecular Weight (g/mol): 515.33
• Formula Weight: 515.33
• Physical Form: Powder

• Absorbance: 0.40 max. (460nm)
• Color: Yellow
• Infrared Spectrum: Authentic
• MDL Number: MFCD00082440
• Specific Rotation Condition: − 242.50 (20.00°C c=0.5,water)
• Synonym: chlortetracycline hydrochloride, 4-epi-chlortetracycline hydrochloride, 2-amino hydroxy methylidene-7-chloro-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride, 2-azanyl oxidanyl methylidene-7-chloranyl-4-dimethylamino-6-methyl-6,10,11,12a-tetrakis oxidanyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione hydrochloride
• InChI Key: QYAPHLRPFNSDNH-CIVPRPTRSA-N
• IUPAC Name: (4S,4aR,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
• PubChem CID: 66577600
• Percent Purity: 94.5 to 102.0% (sum of the contents of chlortetra cycline hydrochloride and tetracycline hydrochloride, dry substance), ≥89.5% (chlortetracycline hydrochloride, dry substance), 8% max. (tetracycline hydrochloride, dry substance)
• Chemical Name or Material: Chlortetracycline hydrochloride

Safety and Handling

GHS H Statement
Causes serious eye irritation.
Causes skin irritation.
May cause respiratory irritation.

GHS P Statement
IF ON SKIN: Wash with plenty of soap and water.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses,if present a

GHS Signal Word: Warning

missing translation for 'einecsNumber' : 200-591-7

Product Identifier

• Chlortetracycline hydrochloride

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H315-Causes skin irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

RUO – Research Use Only