Clozapine N-oxide, Tocris Bioscience™

Description

Activator of muscarinic DREADDs

Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs) in vitro. Silences hippocampal neurons expressing hM4 DREADDs in vitro. Activates Gs-linked DREADDS- AgRP in mice via intracerebroventricular (i.c.v) injection. Shown to be a P-glycoprotein (P-gp) efflux pump substrate. Other potent and selective hM3Dq DREADD agonists available: DREADD agonist 21 and Perlapine .

Water soluble salt also available.

This product contains 1 molar equivalent of ethanol.

Specifications

Chemical Identifiers

• CAS: 34233-69-7
• Molecular Formula: C18H19ClN4O
• Molecular Weight (g/mol): 342.827
• InChI Key: WYRDWWAASBTJLM-UHFFFAOYSA-N
• Synonym: clozapine n-oxide, clozapine-n-oxide, unii-mza8bk588j, chembl1688, mza8bk588j, n-oxyclozapine, clozapine n-oxide cno, oguczbiqsyywef-uhfffaoysa-n
• PubChem CID: 2819
• IUPAC Name: 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
• SMILES: C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]

• Assay Percent Range: >98%
• Quantity: 10 mg
• Formula Weight: 342.82
• Percent Purity: >99%
• Chemical Name or Material: Clozapine N-oxide