Co 101244 hydrochloride, Tocris Bioscience™

Description

GluN2B-selective NMDA antagonist

Novel, potent and selective antagonist of GluN2B (formally NR2B)-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for GluN1A/2B (NR1A/2B), GluN1A/2A (NR1A/2A) and GluN1A/2C (NR1A/2C) subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Specifications

Chemical Identifiers

• CAS: 193356-17-1
• Molecular Formula: C21H28ClNO3
• Molecular Weight (g/mol): 377.909
• InChI Key: WFFZHKKSIDENAJ-UHFFFAOYSA-N
• Synonym: co 101244 hydrochloride, 1-2-4-hydroxyphenoxy ethyl-4-4-methylphenyl methyl piperidin-4-ol hydrochloride, 1-2-4-hydroxyphenoxy ethyl-4-4-methylphenyl methyl-4-piperidinol mono hydrochloride, d08nrh, 1-2-4-hydroxyphenoxy ethyl-4-4-methylphenyl methyl-4-piperidinol monohydrochloride, 1-2-4-hydroxyphenoxy ethyl-4-4-methylphenyl methyl-4-piperidinol hydrochloride, 1-2-4-hydroxyphenoxy ethyl-4-hydroxy-4-4-methylbenzyl piperidine hydrochloride, 1-2-4-hydroxyphenoxy ethyl-4hydroxy-4-4-methylbenzyl piperidine hydrochloride
• PubChem CID: 6918426
• IUPAC Name: 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]piperidin-4-ol;hydrochloride
• SMILES: CC1=CC=C(C=C1)CC2(CCN(CC2)CCOC3=CC=C(C=C3)O)O.Cl

• Quantity: 50 mg
• Formula Weight: 377.91
• Percent Purity: >99%
• Chemical Name or Material: Co 101244 hydrochloride