Thermo Scientific Chemicals Colchicine, 97%

Product Code	Brand	Quantity	Packaging
10185230	Thermo Scientific Chemicals 227125000	500 mg	Glass bottle
10388310	Thermo Scientific Chemicals	1 g	Glass bottle
10174953	Thermo Scientific Chemicals 227120050	5 g	Glass bottle
13428488	Thermo Scientific Chemicals 227120250	25 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• Colchicine (7alphah-colchicine) is an alkaloid found in Colchicum autumnale that has been shown to have anti-gout and anti-inflammatory properties
• Colchicine binds tubulin and prevents the migration of immune cells, reducing inflammation

Applications

• Colchicine is an anti-mitotic; may be used in the study of cell proliferation and migration
• Intended for in vivo and in vitro research applications
• For research use only, not intended to treat disease

Chemical Identifiers

• CAS: 64-86-8
• Molecular Weight (g/mol): 399.44
• InChI Key: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• PubChem CID: 45038708
• SMILES: COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

• Molecular Formula: C22H25NO6
• MDL Number: MFCD00078484,MFCD00078484
• Synonym: colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
• IUPAC Name: 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Specifications

• CAS: 64-86-8
• Color: Yellow
• Assay Percent Range: 96% min. on anhydrous and solvent-free substance (HPLC)
• MDL Number: MFCD00078484,MFCD00078484
• Merck Index: 15,2455
• Synonym: colchicine, colchicina, colchicin, condylon, colchicinum, colchisol, colsaloid, colcin, colchineos, 7alphah-colchicine
• InChI Key: IAKHMKGGTNLKSZ-INIZCTEOSA-N
• IUPAC Name: 2,2,2-trideuterio-N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(trideuteriomethoxy)-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
• PubChem CID: 45038708
• Percent Purity: 97%
• Chemical Name or Material: Colchicine

• Melting Point: 150.0°C to 160.0°C
• Infrared Spectrum: Authentic
• Molecular Formula: C22H25NO6
• Beilstein: 14,IV,946
• Specific Rotation: − 250.00
• Solubility Information: Solubility in water: 45g/l (20°C). Other solubilities: soluble in alcohol and chloroform,practically insoluble in petroleum ether,1g/220mL ether,1g/100mL benzene
• SMILES: COC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
• Molecular Weight (g/mol): 399.44
• Formula Weight: 399.44
• Physical Form: Powder

Safety and Handling

GHS H Statement:
Fatal if swallowed.
May cause genetic defects.

GHS P Statement:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Obtain special instructions before use.
IF exposed or concerned: Get medical advice/attention.

WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.

GHS Signal Word: Danger

missing translation for 'einecsNumber' : 200-598-5

Product Identifier

• Colchicine

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 2
• Germ cell mutagenicity Category 1B

Hazard Statement

• H340-May cause genetic defects.
• H300-Fatal if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only