Crizotinib, Tocris Bioscience™

Description

Potent c-MET/ALK inhibitor

Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.

Specifications

Chemical Identifiers

• CAS: 877399-52-5
• Molecular Formula: C21H22Cl2FN5O
• Molecular Weight (g/mol): 450.34
• MDL Number: MFCD12407409
• InChI Key: KTEIFNKAUNYNJU-UHFFFAOYNA-N
• Synonym: crizotinib, xalkori, r-crizotinib, crizotinibum, 3-1r-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-4-piperidinyl-1h-pyrazol-4-yl-2-pyridinamine, xalkori tn, r-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, crizotinib pf-02341066, 3-1r-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, crizotinib pf-2341066
• PubChem CID: 11626560
• ChEBI: CHEBI:64310
• IUPAC Name: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
• SMILES: CC(OC1=C(N)N=CC(=C1)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl

• Assay Percent Range: >99%
• Quantity: 10 mg
• Formula Weight: 450.34
• Chemical Name or Material: Crizotinib