CSNK2A2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10606-1-AP-150UL

Product Code. 16867093

Description

Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha′) in a homomeric or heteromeric conformation. Whilst the alpha- and alpha′-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha′-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Specifications

• Antigen: CSNK2A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CSNK2A2
• Gene Alias: Casein kinase II subunit alpha, CK II alpha, CK2A2, CSNK2A1, CSNK2A2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1459
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P19784
• Gene Symbols: CSNK2A2
• Immunogen: CSNK2A2 Fusion Protein Ag0877
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG