Tocris Bioscience™ CU-76

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Brand:  Tocris Bioscience™ 7820/2

Product Code. 18796185

Description

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

Specifications

• Chemical Name or Material: Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
• Quantity: 2 mg
• Molecular Formula: C₁₁H₈F₂IN₅O₂

• CAS: 2400954-58-5
• Target: STING/TMEM173
• Purity: 0.98