Cucurbitacin I, Tocris Bioscience™

Description

Selective inhibitor of STAT3/JAK2 signaling

Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

Specifications

• CAS: 2222-07-3
• Molecular Formula: C30H42O7
• Quantity: 1 mg
• Synonym: (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
• InChI Key: NISPVUDLMHQFRQ-MKIKIEMVSA-N
• SMILES: CC1(C2=CCC3C4(CC(C(C4(CC(=O)C3(C2C=C(C1=O)O)C)C)C(C)(C(=O)C=CC(C)(C)O)O)O)C)C
• IUPAC Name: (9S,13S,14R,16S)-17-[(E,2S)-2,6-dihydroxy-6-methyl-3-oxohept-4-en-2-yl]-2,16-dihydroxy-4,4,9,13,14-pentamethyl-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthrene-3,11-dione
• Molecular Weight (g/mol): 514.66
• PubChem CID: 17750994
• Formula Weight: 514.65
• Percent Purity: >98%
• Chemical Name or Material: Cucurbitacin I