Cyclic Pifithrin-α hydrobromide, Tocris Bioscience™

Description

p53 inhibitor

Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone -induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.

Specifications

Chemical Identifiers

• CAS: 511296-88-1
• Molecular Formula: C16H17BrN2S
• Molecular Weight (g/mol): 349.29
• MDL Number: MFCD02683960
• InChI Key: SGNCOAOESGSEOP-UHFFFAOYSA-N
• Synonym: pifithrin-beta hydrobromide, cyclic pifithrin-alpha hydrobromide, pifithrin-alpha, cyclic, unii-up003xxt4d, up003xxt4d, 2-4-methylphenyl imidazo 2,1-b-5,6,7,8-tetrahydrobenzothiazole, hbr, 2-4-methylphenyl imidazo 2,1-b-5,6,7,8-tetrahydrobenzothiazole hydrobromide, cyclic pifithrin-, a hydrobromide, pifithrin-beta hydrobromide mi, cyclic-pifithrin-alpha
• PubChem CID: 11515812
• IUPAC Name: 4-(4-methylphenyl)-7-thia-2,5-diazatricyclo[6.4.0.0²,⁶]dodeca-1(8),3,5-triene hydrobromide
• SMILES: Br.CC1=CC=C(C=C1)C1=CN2C(SC3=C2CCCC3)=N1

• Quantity: 10 mg
• Formula Weight: 349.29
• Percent Purity: >98%
• Chemical Name or Material: Cyclic Pifithrin-α hydrobromide