Cyclophosphamide, Tocris Bioscience™

Description

Alkylating agent; chemotherapeutic

Nitrogen mustard alkylating agent and prodrug. Phosphoramide mustard (active metabolite) forms DNA cross-links leading to cell death. Inhibits aldehyde dehydrogenase 1 (ALDH1) through its degradation product acrolein. Chemotherapeutic for the treatment of breast cancer; regulates Bax and Bcl-2 expression when administered with etoposide (Cat. No. 1226) in breast cancer cell lines.

Specifications

• CAS: 50-18-0
• Molecular Formula: C7H15Cl2N2O2P
• Quantity: 50 mg
• Synonym: cyclophosphamide, cyclophosphamid, cyclophosphane, cytophosphan, procytox, clafen, cytoxan, endoxan, neosar, cyclophosphamidum
• InChI Key: CMSMOCZEIVJLDB-UHFFFAOYSA-N
• SMILES: C1CNP(=O)(OC1)N(CCCl)CCCl
• IUPAC Name: N,N-bis(2-chloroethyl)-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine
• Molecular Weight (g/mol): 261.083
• PubChem CID: 2907
• ChEBI: CHEBI:4027
• Formula Weight: 261.09
• Percent Purity: >99%
• Chemical Name or Material: Cyclophosphamide