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Thermo Scientific™ CYP2E1 BACULOSOMES™ Plus Reagent, rHuman

Cytochrome P450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells infected with recombinant baculovirus containing a human CYP450 isozyme, as well as human cytochrome P450 reductase.

Brand:  Thermo Scientific™ P2948

Product Code. 10328242

  • £209.00 / Each
Estimated Shipment: 09-01-2025
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For Research Use Only. All usage must comply with product instructions.
 
This item is not returnable. View return policy

Description

Description

Cytochrome P450 BACULOSOMES™ Plus Reagents are microsomes prepared from insect cells infected with recombinant baculovirus containing a human CYP450 isozyme, as well as human cytochrome P450 reductase. For this particular isozyme (CYP2E1), human cytochrome b5 is also included.

  • Single human P450 isozyme for detailed drug metabolism studies
  • High specific activity increases dynamic range and sensitivity
  • No background metabolism for clear results

Single Overexpressed Human CYP450 Isozyme

CYP450 BACULOSOMES™ Plus Reagents offer a distinct advantage over Human Liver Microsomes (HLMs) in that only one CYP450 isozyme is expressed, thereby preventing metabolism by other CYP450s or other classes of drug metabolizing enzymes.

High Activity Results in Increased Sensitivity

Compound rankings based on metabolism and inhibition profiles observed with CYP450 BACULOSOMES™ Plus Reagents are very similar to those seen with HLMs for most compounds tested. However, CYP450 BACULOSOMES™ Plus Reagents activity and metabolic rates with most substrates is significantly higher than those seen with HLMs. This results in a broad dynamic range and high sensitivity in assays utilizing CYP450 BACULOSOMES™ Plus Reagents. The high level of activity and reproducibility of the enzyme component observed in the reaction with most probe substrates makes CYP450 BACULOSOMES™ Plus Reagents well suited to high-throughput screening formats.

High Signal to Noise Ratio

No background metabolism by endogenous insect CYP450s has been detected with any of the Vivid™ probe substrates tested so far.

Applications

  • Isozyme identification
  • DMPK analysis
  • Isozyme-specific metabolism
  • Inhibition screening
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CYP2E1 BACULOSOMES™ Plus Reagent, 1nmol, Liquid, 7.3mg/mL Concentration, Toxicology and Drug Metabolism Research Category, Dry Ice, –80°C Storage Temperature, For Research Use only, Used for Cell Viability, Proliferation and Function, Pharma and Biopharma
BACULOSOMES™
Cell viability, proliferation and function, pharma and biopharma, protein assays and analysis, target-based ADME/Tox assays
Store at -80°C.
1 nmol
Toxicology & Drug Metabolism
7.3mg/mL
Liquid
1nmol
Bacterial Microsome
Dry Ice
Human
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For Research Use Only. Not for use in diagnostic procedures.