Cytarabine, 98%, Thermo Scientific Chemicals

Description

Cytarabine, CAS # 147-94-4, is an inhibitor of DNA synthesis that is used as an anticancer and antiviral agent.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Cytarabine is a nucleoside analog that acts as an antileukemic agent

Cytarabine becomes cytotoxic following conversion to its triphosphorylated form, which can be incorporated into DNA primers by DNA polymerase alpha

Can induce S phase cell cycle arrest and apoptosis in leukemic and neuronal cells

Applications

Has been used to study chemotherapeutic regimens in laboratory studies of leukemia

Useful for laboratory studies of cytarabine resistance mechanisms

At nanomolar concentrations, cytarabine has been seen to induce mitochondrial apoptosis in leukemic cells through upregulation of multiple Bcl-2 family members

It can induce neuronal cell death via inducing γ-H2AX phosphorylation in histones, in the absence of double-stranded DNA breaks

Specifications

Chemical Identifiers

• CAS: 147-94-4
• Molecular Formula: C₉H₁₃N₃O₅
• Molecular Weight (g/mol): 243.22
• InChI Key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• Synonym: cytarabine, cytosine arabinoside, ara-c, arabinocytidine, cytosar, arabinosylcytosine, aracytidine, cytarabin, cytarabinoside, tarabine
• PubChem CID: 6253
• ChEBI: CHEBI:28680
• IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

• Melting Point: 220.0°C
• Assay Percent Range: 97.5% min. (HPLC)
• Packaging: Glass bottle
• Quantity: 100 mg
• Merck Index: 152781
• Solubility Information: Solubility in water: soluble. Other solubilities: soluble in dmso, ethanol
• Formula Weight: 243.22
• Percent Purity: 98%
• Chemical Name or Material: Cytarabine

Safety and Handling

Product Identifier

• Cytosine beta-D-arabinofuranoside

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 2
• Respiratory sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H361d-Suspected of damaging the unborn child.
• H319-Causes serious eye irritation.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

RUO – Research Use Only