Thermo Scientific Chemicals Cytochalasin B

Description

Cytochalasin B, CAS# 14930-96-2, also known as phomin, is an organic heterotricyclic compound that is a cell-permeable mycotoxin with potent activity to inhibit cytoplasmic division.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Cytochalasin B is a cell-permeable fungal toxin / mycotoxin considered to be an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments

Applications

• Cytochalasin B can inhibit platelet aggregation and actin polymerization
• Cytochalasin B is commonly used in studies on cytokinesis due to its ability to act as an inhibitor
• It is used for characterizing some of the polymerization properties of actin
• This compound can also induce DNA fragmentation, inhibit cell division, and inhibit glucose transport, among other molecular processes
• It could be used as a probe for the two hexose-transport systems in rat L6 myoblasts
• Cytochalasin B is commonly used in studies of glucose transporters (GLUT)
• It can be used in in vitro micronucleus assay protocols

Specifications

Chemical Identifiers

• CAS: 14930-96-2
• Molecular Formula: C29H37NO5
• Molecular Weight (g/mol): 479.62
• MDL Number: MFCD00077704
• InChI Key: GBOGMAARMMDZGR-UHFFFAOYNA-N
• Synonym: cytochalasin b, cytochalasin b from helminthosporium dematioideum
• PubChem CID: 44634701
• IUPAC Name: 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-2H,5H,6H,7H,8H,9H,10H,12aH,13H,14H,15H,15aH,16H,17H,18H-oxacyclotetradeca[3,2-e]isoindole-2,18-dione
• SMILES: CC1C2C(CC3=CC=CC=C3)NC(=O)C22OC(=O)C=CC(O)CCCC(C)CC=CC2C(O)C1=C

• Melting Point: 218.0°C to 223.0°C
• Color: White
• Infrared Spectrum: Authentic
• Packaging: Glass bottle
• Quantity: 5 mg
• Merck Index: 15, 2787
• Specific Rotation: + 89.00
• Solubility Information: Solubility in water: insoluble. Other solubilities: 10.3 mg/mL acetone - 35.4 mg/mL ethanol (24 c), 371 mg/mL dmso - 492 mg/mL dmf (24 c)
• Formula Weight: 479.6
• Percent Purity: ≥98%
• Physical Form: Powder
• Chemical Name or Material: Cytochalasin B

Safety and Handling

Product Identifier

• Cytochalasin B

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Acute toxicity Category 2
• Reproductive toxicity Category 2

Hazard Statement

• H310-Fatal in contact with skin.
• H330-Fatal if inhaled.
• H300-Fatal if swallowed.,Fatal if swallowed.
• H361-Suspected of damaging fertility or the unborn child.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P302+P350-IF ON SKIN: Gently wash with plenty of soap and water.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P310-Immediately call a POISON CENTER/doctor/.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only