Cytokeratin Pan Monoclonal Antibody (MNF116), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA126237

Product Code. 11549462

Description

Recommended positive controls: Skin. This antibody reacts Cytokeratin 5, Cytokeratin 6, Cytokeratin 8, Cytokeratin 17 and Cytokeratin 19.

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.

Specifications

• Antigen: Cytokeratin Pan
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: tissue culture supernatant with 0.09% sodium azide
• Gene Accession No.: P02533, P02538, P04264, P05783, P05787, P08727, P08729, P08779, P12035, P13645, P13646, P13647, P19012, P19013, P35908, Q01546, Q04695, Q7Z794
• Gene Symbols: KRT1, KRT10, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT3, KRT4, KRT5, Krt6a, KRT7, KRT76, KRT77, KRT8
• Immunogen: Crude extract of splenic cells from a nude mouse engrafted with MCF-7 cells.
• Regulatory Status: RUO
• Gene ID (Entrez): 374454, 3848, 3849, 3850, 3851, 3852, 3853, 3855, 3856, 3858, 3860, 3861, 3866, 3868, 3872, 3875, 3880, 51350
• Content And Storage: 4° C, do not freeze
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: MNF116
• Conjugate: Unconjugated
• Gene: KRT3
• Gene Alias: 2310016L08Rik; 3300001P10Rik; 39.1; 40-kDa keratin intermediate filament; 47 kDa cytokeratin; 56 kDa cytokeratin; 57kd keratin; 57kDa keratin; 58 kDa cytokeratin; 60-kDa keratin; 63kDa Keratin; 65 kDa cytokeratin; 67 kDa cytokeratin; AA960620; adult keratin; AI324768; AI528832; AI626930; AI663979; AL022697; alpha keratin; AU019895; AW108092; AW146334; basic epidermal type II cytokeratin (carboxy-terminal region, clone pUF164); BB005427; BCIE; BIE; Card2; cell proliferation-inducing gene 46 protein; CK 2e; CK1; CK-1; CK10; CK-10; CK13; CK-13; CK14; CK-14; CK15; CK-15; CK16; CK-16; CK-17; CK18; CK-18; CK19; CK-19; CK-1B; CK-2e; CK3; CK-3; CK4; CK-4; CK5; CK-5; ck55; CK6A; CK-6A; CK6C; CK-6C; CK6D; CK-6D; CK-6E; CK7; CK-7; CK8; CK-8; CYK18; CYK4; CYK8; CYKER; cytokeratin 1; cytokeratin 10; cytokeratin 13; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 3; cytokeratin 4; cytokeratin 5; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; cytokeratin 7
• Host Species: Mouse
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1