D 4476, Tocris Bioscience™

Description

Selective CK1 inhibitor. Also inhibits TGF-βRI

Selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

Specifications

Chemical Identifiers

• CAS: 301836-43-1
• Molecular Formula: C23H18N4O3
• Molecular Weight (g/mol): 398.422
• InChI Key: DPDZHVCKYBCJHW-UHFFFAOYSA-N
• Synonym: ck1 inhibitor, casein kinase i inhibitor, d4476, casein kinase i inhibitor, 4-4-2,3-dihydrobenzo 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, 4-4-2,3-dihydrobenzo b 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, benzamide,4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl benzamide, insolution casein kinase i inhibitor, d4476, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide
• PubChem CID: 6419753
• IUPAC Name: 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
• SMILES: C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

• Quantity: 50 mg
• Formula Weight: 398.41
• Percent Purity: >99%
• Chemical Name or Material: D 4476