missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organoheterocyclic compounds
  6. Azoles
  7. Imidazoles
  8. D 4476, Tocris Bioscience™

D 4476, Tocris Bioscience™

Product Code. 18054172
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective CK1 inhibitor. Also inhibits TGF-βRI

Selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

Chemical Identifiers

CAS 301836-43-1
Molecular Formula C23H18N4O3
Molecular Weight (g/mol) 398.422
InChI Key DPDZHVCKYBCJHW-UHFFFAOYSA-N
Synonym ck1 inhibitor, casein kinase i inhibitor, d4476, casein kinase i inhibitor, 4-4-2,3-dihydrobenzo 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, 4-4-2,3-dihydrobenzo b 1,4 dioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide, benzamide,4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-2-pyridinyl-1h-imidazol-2-yl benzamide, insolution casein kinase i inhibitor, d4476, 4-4-2,3-dihydro-1,4-benzodioxin-6-yl-5-pyridin-2-yl-1h-imidazol-2-yl benzamide
PubChem CID 6419753
IUPAC Name 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
SMILES C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Specifications

Quantity 50 mg
Formula Weight 398.41
Percent Purity >99%
Chemical Name or Material D 4476
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.