Daptomycin, Tocris Bioscience™

Description

Antibiotic; inhibits protein, DNA and RNA synthesis in gram-positive bacteria

Daptomycin is a lipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as MRSA and VRE. Disrupts plasma membrane function; activity results in membrane depolarization leading to inhibition of protein, DNA and RNA synthesis.

Specifications

Chemical Identifiers

• CAS: 103060-53-3
• Molecular Formula: C72H101N17O26
• Molecular Weight (g/mol): 1620.693
• InChI Key: DOAKLVKFURWEDJ-AVSAZHKKSA-N
• Synonym: N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α, 2-
• PubChem CID: 133640189
• SMILES: CCCCCCCCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC3C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)C(C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C

• Type: Daptomycin
• Formula Weight: 1620.67
• Percent Purity: >95%
• Quantity: 10 mg
• Chemical Name or Material: Daptomycin