DCA, Tocris Bioscience™

Description

Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor

Inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Decreases tumor growth in vitro and in vivo.

Specifications

• CAS: 2156-56-1
• Quantity: 100 mg
• Molecular Formula: C2HCl2NaO2
• MDL Number: MFCD00070489
• Synonym: sodium dichloroacetate, sodium 2,2-dichloroacetate, dichloroacetic acid sodium salt, acetic acid, dichloro-, sodium salt, ceresine, dichloroacetate sodium, dichloroctan sodny czech, sodium dichloroacetate usan, ccris 7697, dichloroacetic acid, sodium salt
• InChI Key: LUPNKHXLFSSUGS-UHFFFAOYSA-M
• SMILES: [Na+].[O-]C(=O)C(Cl)Cl
• IUPAC Name: sodium 2,2-dichloroacetate
• Molecular Weight (g/mol): 150.92
• PubChem CID: 517326
• Formula Weight: 150.92
• Percent Purity: >98%
• Chemical Name or Material: DCA