Deguelin, MedChemExpress

MedChemExpress Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

Brand:  Medchem Express HY-13425

Product Code. 16485678

Description

Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

Specifications

• Chemical Name or Material: Deguelin
• Color: Light Yellow
• Molecular Formula: C₂₃H₂₂O₆
• Synonym: (-)-Deguelin (-)-cis-Deguelin
• SMILES: O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C=CC(C)(C)OC5=CC=C14
• Formula Weight: 394.42
• Grade: Research
• For Use With (Application): Cancer-Kinase/protease

• CAS: 522-17-8
• Purity Grade Notes: Research
• Quantity: 10 mg
• Solubility Information: DMSO : 100 mg/mL (253.54 mM; Need ultrasonic)
• Molecular Weight (g/mol): 394.42
• Percent Purity: 98.0%
• Physical Form: Solid

Research purposes only