Deoxynivalenol, Tocris Bioscience™

Description

Mycotoxin; potent protein synthesis inhibitor

Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Specifications

• CAS: 51481-10-8
• Molecular Formula: C15H20O6
• MDL Number: MFCD09039270
• Quantity: 1 mg
• Synonym: deoxynivalenol, vomitoxin, dehydronivalenol, 4-deoxynivalenol, 4-desoxynivalenol, desoxynivalenol, unii-jt37hyp23v, ccris 7801, rd toxin, jt37hyp23v
• InChI Key: LINOMUASTDIRTM-QGRHZQQGSA-N
• SMILES: CC1=C[C@H]2O[C@@H]3[C@H](O)C[C@@](C)([C@]33CO3)[C@@]2(CO)[C@H](O)C1=O
• IUPAC Name: (1'R,2S,2'R,3'S,7'R,9'R,10'R)-3',10'-dihydroxy-2'-(hydroxymethyl)-1',5'-dimethyl-8'-oxaspiro[oxirane-2,12'-tricyclo[7.2.1.0²,⁷]dodecan]-5'-en-4'-one
• Molecular Weight (g/mol): 296.32
• PubChem CID: 40024
• Formula Weight: 296.32
• Percent Purity: 98%
• Chemical Name or Material: Deoxynivalenol