Tocris Bioscience™ des-His1-[Glu9)-Glucagon (1-29) amide

Glucagon receptor antagonist

Brand:  Tocris Bioscience™ 2216/1

Product Code. 18004092

Description

des-His1-[Glu9]-Glucagon (1-29) amide is a glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

Specifications

• Purity: 95%
• Description: des-His1-[Glu9)-Glucagon (1-29) amide
• Product Type: des-His¹-[Glu⁹]-Glucagon (1-29) amide
• Sequence: Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2

• Content And Storage: Store at -20°C
• Molecular Weight (g/mol): 3358.68
• Quantity: 1 mg

For Research Use Only