Dexmedetomidine hydrochloride, Tocris Bioscience™

Description

Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)

Dexmedetomidine hydrochloride is an active isomer of medetomidine, a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively). Displays greater selectivity over α1-adrenoceptors than Clonidine (Cat. No. 0690) and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.

Racemate also available.

Specifications

Chemical Identifiers

• CAS: 145108-58-3
• Molecular Formula: C13H17ClN2
• Molecular Weight (g/mol): 236.743
• InChI Key: VPNGEIHDPSLNMU-MERQFXBCSA-N
• Synonym: dexmedetomidine hydrochloride, dexmedetomidine hcl, precedex, 4-s-alpha,2,3-trimethylbenzyl imidazole monohydrochloride, unii-1018wh7f9i, dexmedetomidine hcl precedex, s-5-1-2,3-dimethylphenyl ethyl-1h-imidazole hydrochloride, dexdor, 4-1s-1-2,3-dimethylphenyl ethyl-1h-imidazole hydrochloride
• PubChem CID: 6918081
• ChEBI: CHEBI:31472
• IUPAC Name: 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
• SMILES: CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl

• Quantity: 10 mg
• Formula Weight: 236.74
• Percent Purity: 98%
• Chemical Name or Material: Dexmedetomidine hydrochloride