DICER1 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16850125	Proteintech 20567-1-AP-20UL	20 μL
16840125	Proteintech 20567-1-AP-150UL	150 μL

Description

The antibody is specific to DICER1. The calculated molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 has isoforms with molecular weight 219 kDa and 93 kDa.

Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.

Specifications

• Antigen: DICER1
• Applications: Immunocytochemistry, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9UPY3
• Gene ID (Entrez): 23405
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: DICER1

• Concentration: 0.57 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: DCR1, Dicer, dicer 1, ribonuclease type III, DICER1, Endoribonuclease Dicer, Helicase MOI, Helicase with RNase motif, HERNA, KIAA0928
• Gene Symbols: DICER1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody