Diphenyleneiodonium chloride, Tocris Bioscience™

Description

GPR3 agonist; also inhibits NOS and NADPH oxidases

GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation.

Specifications

Chemical Identifiers

• CAS: 4673-26-1
• Molecular Formula: C12H8ClI
• Molecular Weight (g/mol): 314.55
• InChI Key: FCFZKAVCDNTYID-UHFFFAOYSA-M
• Synonym: diphenyleneiodonium chloride, dibenziodolium chloride, unii-7m9d81yz2n, dpi, 8? 3-iodatricyclo 7.4.0.0 2 ,? trideca-1 13 ,2,4,6,9,11-hexaen-8-ylium chloride, dibenziodolium, chloride, d0n0gj, c12h8i.cl, dibenzo b,d iodolium chloride, 2,2'-biphenylyleneiodonium chloride
• PubChem CID: 2733504
• ChEBI: CHEBI:77967
• SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-]

• Quantity: 10 mg
• Formula Weight: 314.55
• Percent Purity: >99%
• Chemical Name or Material: Diphenyleneiodonium chloride