DL-TBOA, Tocris Bioscience™

Description

Selective non-transportable inhibitor of EAATs

DL-TBOA is a competitive, non-transportable blocker of excitatory amino acid transporters (IC50 values are 6 μM, 6 μM and 70 μM, for EAAT2, EAAT3 and EAAT1 respectively). DL-TBOA also inhibits EAAT4 and EAAT5 (Ki values are 4.4 μM and 3.2 μM respectively). DL-TBOA displays high selectivity for EAATs over ionotropic and metabotropic glutamate receptors. DL-TBOA augments SN 38 (Cat. No. 2684) induced colorectal cancer cell death in drug-resistant cell lines. DL-TBOA enhances synaptic activity in the frog labyrinth.

Specifications

Chemical Identifiers

• CAS: 205309-81-5
• Molecular Formula: C11H13NO5
• Molecular Weight (g/mol): 239.227
• InChI Key: BYOBCYXURWDEDS-IUCAKERBSA-N
• Synonym: dl-tboa, chembl79140, dl-threo-beta-benzyloxyaspartate, 3s-3-benzyloxy-l-aspartic acid, 2s,3s-2-amino-3-benzyloxy succinic acid, tboa, 2s,3s-2-amino-3-benzyloxy-succinic acid, tocris-1223, d07gub, l-threo-benzyloxy aspartate
• PubChem CID: 5311218
• IUPAC Name: (2S,3S)-2-amino-3-phenylmethoxybutanedioic acid
• SMILES: C1=CC=C(C=C1)COC(C(C(=O)O)N)C(=O)O

• Formula Weight: 239.23
• Percent Purity: >98%
• Quantity: 50 mg
• Chemical Name or Material: DL-TBOA