Doxorubicin Hydrochloride, Fisher BioReagents

Description

Doxorubicin Hydrochloride

Doxorubicin HCL is a chemotherapeutic agent. Antitumor, immunosuppressive, and antibiotic agent. It blocks RNA polymerase and reverse transcriptase. Also inhibits nucleic acid synthesis.

Specifications

Chemical Identifiers

• CAS: 25316-40-9
• Molecular Formula: C27H30ClNO11
• Molecular Weight (g/mol): 579.98
• MDL Number: MFCD00077757,MFCD00077757,MFCD00941448
• InChI Key: MWWSFMDVAYGXBV-FGBJBKNOSA-N
• Synonym: doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs
• PubChem CID: 129626538
• IUPAC Name: (7R,9R)-7-[(2S,4R,5R,6R)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
• SMILES: [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O

• Decomposition Information: 216°C
• Melting Point: 216°C
• Color: Orange
• Assay Percent Range: (by HPLC): ≥95%
• Packaging: Amber Glass
• Quantity: 1 mg
• Merck Index: 15, 3487
• Solubility Information: Soluble in water
• Formula Weight: 580
• Physical Form: Powder or Solid
• Chemical Name or Material: Doxorubicin Hydrochloride

Safety and Handling

Product Identifier

• Doxorubicin hydrochloride

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Carcinogenicity Category 1B
• Serious eye damage/eye irritation Category 1
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H318-Causes serious eye damage.
• H340-May cause genetic defects.
• H350-May cause cancer.
• H315-Causes skin irritation.
• H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
• H335-May cause respiratory irritation.
• H302-Harmful if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.