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DR1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA563106
This item is not returnable.
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Description
Immunogen sequence: EVKEVLQECK TVALKRRKAS SRLENLGIPE EELLRQQQEL FAKARQQQAE LAQQEWLQMQ Q Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Specifications
| DR1 | |
| Polyclonal | |
| Unconjugated | |
| Dr1 | |
| 1700121L09Rik; Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); Dr1; Dr1l; NC2; NC2B; NC2beta; NC2-beta; negative cofactor 2; negative cofactor 2 beta; negative cofactor 2-beta; Protein Dr1; similar to down-regulator of transcription 1; TATA-binding protein-associated phosphoprotein; wu:fj15f04; zgc:152914 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 1810 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q01658 | |
| Dr1 | |
| Recombinant protein corresponding to Human DR1 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
Research Use Only