Dynasore, Tocris Bioscience™

Description

Non-competitive dynamin inhibitor

Dynasore is a non-competitive reversible inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Dynasore blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells. Dynasore attenuates motor symptoms in an animal model of Parkinson's disease and in a cellular model of Alzheimer's disease it reduces tau protein aggregation and internalization.

Specifications

Chemical Identifiers

• CAS: 304448-55-3
• Molecular Formula: C18H14N2O4
• Molecular Weight (g/mol): 322.32
• MDL Number: MFCD00292551
• InChI Key: NRQJUIHYFNUXFT-UHFFFAOYSA-N
• Synonym: dynamin inhibitor i, dynasore, n'-3,4-dihydroxybenzylidene-3-hydroxy-2-naphthohydrazide, 3-hydroxy-n'-3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene methyl naphthalene-2-carbohydrazide, dynasore monohydrate, n'-1e-3,4-dihydroxyphenyl methylidene-3-hydroxynaphthalene-2-carbohydrazide, n'-3,4-dihydroxyphenyl methylidene-3-hydroxynaphthalene-2-carbohydrazide, 2-naphthalenecarboxylicacid, 3-hydroxy-, 2-3,4-dihydroxyphenyl methylene hydrazide
• PubChem CID: 6739924
• IUPAC Name: 3-hydroxy-N'-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]naphthalene-2-carbohydrazide
• SMILES: OC1=CC(=CNNC(=O)C2=CC3=CC=CC=C3C=C2O)C=CC1=O

• Quantity: 10 mg
• Formula Weight: 322.32
• Percent Purity: >99%
• Chemical Name or Material: Dynamin Inhibitors