E-cadherin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16850455	Proteintech 20874-1-AP-20UL	20 μL
16840455	Proteintech 20874-1-AP-150UL	150 μL

Description

This polyclonal antibody recognizes 120 kDa intact E-cadherin and its 80 kDa trypsin-cleaved fragment.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintece of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Specifications

• Antigen: E-cadherin
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Rat, Human, Mouse
• Gene Accession No.: P09803, P12830, Q9R0T4
• Gene ID (Entrez): 12550, 83502, 999
• Immunogen: E-cadherin Fusion Protein Ag14973
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CDH1

• Concentration: 0.34 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin
• Gene Symbols: Cdh1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody