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EBI3 (IL-27 subunit) Monoclonal Antibody (ebic6), APC, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen 17-7358-42
Description
EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35 (1-3). Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.
EBI3 (IL-27 subunit) Monoclonal antibody specifically detects EBI3 (IL-27 subunit) in Human samples. It is validated for Flow Cytometry.Specifications
EBI3 (IL-27 subunit) | |
Monoclonal | |
5 μL/Test | |
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
Q14213 | |
EBI3 | |
Human IL-27 recombinant protein | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG2b κ |
Flow Cytometry | |
ebic6 | |
APC | |
EBI3 | |
cytokine receptor; EBI3; EBI-3; EBV-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus induced gene 3; Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor); epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein homolog; IL-27; IL27 subunit; IL-27 subunit beta; IL27B; IL-27B; IL35 subunit; interleukin-27 subunit beta | |
Mouse | |
Affinity chromatography | |
RUO | |
10148 | |
4° C, store in dark, DO NOT FREEZE! | |
Liquid |
For Research Use Only.