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Tocris Bioscience™ EED 226
Potent and selective EED inhibitor
£128.00 - £486.00
Specifications
| Chemical Name or Material | N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine |
|---|---|
| CAS | 2083627-02-3 |
| Target | EED |
| Molecular Formula | C17H15N5O3S |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18727786
|
Tocris Bioscience™
7762/10 |
10 mg |
£128.00
10mg |
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|
18719266
|
Tocris Bioscience™
7762/50 |
50 mg |
£486.00
50mg |
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Description
EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor. It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED. The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes. In vitro, EED 226 regulates histone H3K27 methylation and PRC2 target gene expression. In vivo, it induces tumor regression in a mouse xenograft model. EED 226 is orally bioavailable.Specifications
| N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine | |
| 2083627-02-3 | |
| EED | |
| C17H15N5O3S |
Safety and Handling
Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.