Eeyarestatin I, Tocris Bioscience™

Description

Potent inhibitor of ER-associated protein degradation and translocation

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquitinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA. Also enhances adeno-associated viral transduction in multiple cells types.

Specifications

• CAS: 412960-54-4
• Molecular Formula: C₂₇H₂₅Cl₂N₇O₇
• Quantity: 10 mg
• Synonym: 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5, 5-dimethyl-2-oxo-1-imidazolidineacetic acid 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
• Formula Weight: 630.44
• Percent Purity: >98%
• Chemical Name or Material: Eeyarestatin I