endo-IWR 1, Tocris Bioscience™

Description

Wnt/β-catenin signaling inhibitor; axin stabilizer

endo-IWR 1 is an inhibitor of Wnt signaling. Induces an increase in axin2 protein levels; promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. Promotes endothelial cell specification of cardiac progenitor cells

Negative Control also available.

For more information about how endo-IWR 1 may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail) .

Specifications

Chemical Identifiers

• CAS: 1127442-82-3
• Molecular Formula: C25H19N3O3
• Molecular Weight (g/mol): 409.445
• InChI Key: ZGSXEXBYLJIOGF-HRQSHJORSA-N
• Synonym: iwr-1-endo, iwr-1
• PubChem CID: 91885421
• SMILES: C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6

• Quantity: 10 mg
• Formula Weight: 409.44
• Percent Purity: >98%
• Chemical Name or Material: endo-IWR 1