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Entacapone, Tocris Bioscience™

Product Code. 30001556
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Quantity:
10 mg
50 mg
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Description

Potent COMT inhibitor; blocks α-synuclein aggregation

Potent catechol O-methyltransferase (COMT) inhibitor (IC50 values are 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively). Increases bioavailability of levodopa when given as an adjunct therapy for Parkinson's disease. Inhibits α-synuclein aggregation in an in vitro assay; blocks α-synuclein-induced cell death in PC-12 cells.

Chemical Identifiers

CAS 130929-57-6
Molecular Formula C14H15N3O5
Molecular Weight (g/mol) 305.29
MDL Number MFCD00866580
InChI Key JRURYQJSLYLRLN-BJMVGYQFSA-N
Synonym entacapone, comtan, comtess, entacaponum, entacapona, entacaponum inn-latin, entacapona inn-spanish, entacom, entacapone usan:inn, 2-cyano-n,n-diethyl-3-3,4-dihydroxy-5-nitrophenyl propenamide
PubChem CID 5281081
ChEBI CHEBI:4798
IUPAC Name (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
SMILES CCN(CC)C(=O)C(=C\C1=CC(O)=C(O)C(=C1)[N+]([O-])=O)\C#N

Specifications

Quantity 10 mg
Formula Weight 305.29
Percent Purity >99%
Chemical Name or Material Entacapone
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